The San Diego Padres hosted the Pittsburgh Pirates at Petco Park in San Diego, California, in front of a crowd of 42,471 fans on May 31, 2025. Unfortunately for the Padres, it was a tough night as the Pittsburgh Pirates emerged victorious with a 5-0 win.

The Pirates got on the board early in the first inning when Bryan Reynolds singled to left field, allowing Cruz to score and giving the Pirates a 1-0 lead. They extended their lead in the fourth inning with a single by Ke'Bryan Hayes that brought home Frazier. Andrew McCutchen then added to the lead with a solo home run in the fifth inning. The Pirates continued to pile on the runs in the seventh inning with Reynolds doubling to bring in two more runs, followed by Horwitz singling to left field, bringing the score to 5-0.

The Padres struggled to get their offense going throughout the game, managing only two hits against the Pirates' pitching staff. Martín Maldonado had one of the hits, which was the only one that left the infield.

Social media reactions highlighted the Padres' offensive struggles throughout the game and the month of May as a whole. Fans expressed disappointment in the team's performance and called for improvements in the upcoming games.

Despite the loss, fans showed support for the San Diego Padres, hoping that the team can bounce back and find their form in the next games. The next matchup between the San Diego Padres and the Pittsburgh Pirates is set to take place on June 1, 2025, at Petco Park.