**Fantasy Football Week 6: Key Player Updates and Inactive Reports**

As fantasy football managers gear up for another thrilling week, staying informed about player statuses is essential. Here's the latest on who's in and who's out for this week's NFL action, helping you set the optimal lineup for your fantasy team.

In Denver, wide receiver Josh Reynolds is out with a hand injury. Fantasy managers will need to wait at least another week for his return, keeping Devaughn Vele and Lil'Jordan Humphrey's limited fantasy value intact for now.

The Las Vegas Raiders face a significant shakeup in their backfield. Running backs Alexander Mattison and Zamir White are both doubtful, with ankle and quad injuries respectively. This opens the door for Ameer Abdullah and Dylan Laube to take on more prominent roles.

Seattle's tight end Noah Fant is questionable with a groin injury and could be a game-time decision. The Seahawks are also monitoring wide receiver Tyler Lockett, who was added to the injury report late on Friday with a foot issue.

San Francisco 49ers' quarterback Brock Purdy is sidelined due to a shoulder injury, paving the way for Brandon Allen to start. This situation could impact the fantasy performance of all 49ers' receivers.

Philadelphia Eagles' wide receiver DeVonta Smith will miss the game because of a hamstring injury, ensuring Jahan Dotson will see playing time alongside A.J. Brown.

In Carolina, kicker Eddy Pineiro, who injured his knee during the Panthers' last win, is active and expected to play. Running back Jonathon Brooks, also active, will make his debut and is anticipated to reduce Chuba Hubbard's workload, especially with Miles Sanders being out due to an ankle injury landing him on injured reserve. Wide receiver Adam Thielen, limited in practice all week, is active but may play in a reduced capacity. Jalen Coker, another wide receiver for the Panthers, is inactive with a quad injury.

Chicago Bears running back D'Andre Swift is active after a full practice on Friday, although his carry split with Roschon Johnson remains uncertain. Wide receiver Keenan Allen is also active despite an ankle injury, with Rome Odunze and DJ Moore ready to step up if Allen struggles.

Dallas Cowboys' tight end Jake Ferguson is out with a concussion, leaving Luke Schoonmaker or Brevyn Spann-Ford as alternatives in desperate situations. Wide receiver Brandin Cooks remains on injured reserve, resulting in CeeDee Lamb being the sole fantasy-relevant receiver for the Cowboys.

Kansas City Chiefs running back Isiah Pacheco will stay on injured reserve for another week with a leg injury, handing Kareem Hunt the starting RB role for Sunday's matchup.

Minnesota Vikings tight end Josh Oliver is out with a wrist injury, likely increasing T.J. Hockenson's snap count.

New York Giants' wide receivers Malik Nabers and Darius Slayton are active, though this unit is less appealing fantasy-wise with rookie QB Tommy DeVito taking snaps following Daniel Jones' release.

Tampa Bay Buccaneers' wide receiver Mike Evans is active and should play barring any pregame setbacks.

Tennessee Titans' running back Tyjae Spears will sit out with a concussion, giving Tony Pollard another opportunity to shine in the backfield.

Washington's kicker Austin Seibert is active again, replacing Zane Gonzalez who's back on the practice squad.

Refresh your feeds frequently for the latest updates, and plan your lineups accordingly to ensure you're fielding the best team possible in this critical week of fantasy football.