### Bills Look to Secure AFC East Title Amidst Roster Challenges for 49ers

The Buffalo Bills are gearing up to solidify their AFC East dominance with a fifth-straight title within reach, facing a somewhat depleted San Francisco 49ers team amidst challenging weather conditions. Highmark Stadium will host the Sunday Night Football showdown with Buffalo bringing nearly their full lineup, whereas the 49ers are significantly impacted by injuries.

Friday's injury report brings an optimistic outlook for Buffalo, who have only ruled out two players, with three others deemed questionable. Rookie receiver Tylan Grable remains sidelined, yet to make an active roster appearance since suffering a groin and oblique injury earlier this season. Tight end Dalton Kincaid, battling a knee injury from a Week 11 clash with the Kansas City Chiefs, also continues to be unavailable. The team was hoping the bye week would provide sufficient recovery time, but Kincaid has not returned to practice.

Among those listed as questionable is wide receiver Keon Coleman. After sustaining a wrist injury in Week 9 and missing several games, Coleman has been in limited practice sessions and remains in a no-contact jersey. His status remains uncertain for Sunday's game, keeping fans and the team on edge about his availability.

The return of linebacker Matt Milano is highly anticipated, as he has been a full participant in practice for the first time in over a year. Despite his questionable status, there is optimism about his return to active play, pending further evaluations. The Bills have a roster spot ready for Milano, especially following the placement of linebacker Baylon Spector on Injured Reserve two weeks ago.

Defensive tackle DeWayne Carter, also listed as questionable, has been out since late October and is nearing eligibility for activation from IR. The Bills will need to make strategic adjustments to accommodate him if they decide to bring him back for the game.

The 49ers, on the other hand, face a more challenging situation with significant defensive losses. Key players like defensive end Nick Bosa, defensive tackle Jordan Elliott, and cornerback Deommodore Lenoir have been ruled out. Additionally, linebackers Dre Greenlaw and Demetrius Flannigan-Fowles are not expected to play, further straining the 49ers’ roster.

With such contrasting injury scenarios, Sunday's game will test Buffalo's depth and San Francisco’s resilience. Football fans can expect a compelling contest influenced by the weather, strategic plays, and the players' determination to overcome physical setbacks.