The Minnesota Vikings will face a tough challenge in their attempt to secure a 2-0 record as they take on the San Francisco 49ers this weekend. However, they will have to do so without the help of wide receiver Jordan Addison, who has been ruled out for the upcoming game. Vikings head coach Kevin O'Connell confirmed the news during his Friday press conference, stating that Addison will not be available due to an ankle injury sustained during last Sunday's victory over the New York Giants.

Addison's absence is a blow to the Vikings' offense, as he played a key role in their opening win. His dynamic presence on the field and ability to stretch the defense will surely be missed. The young receiver has not been able to participate in practice throughout the week, making it clear that he needs more time to recover before returning to action.

In addition to Addison, the Vikings could also be without several other starters for the game against the 49ers. Safety Harrison Smith, a crucial component of Minnesota's defense, was added to the injury report after missing Thursday's practice due to a hip injury. Smith's status for the game remains uncertain, as he will be listed as questionable and his progress will be closely monitored leading up to kickoff.

On the offensive side, right tackle Brian O'Neill and right guard Ed Ingram are also listed as questionable for Sunday's matchup. O'Neill has been dealing with an elbow issue, which landed him on Thursday's injury report. Meanwhile, Ingram's triceps injury makes him a Friday addition to the list of questionable players. Like Smith, their availability will be determined closer to game day based on their recovery progress.

Losing key players like Addison, Smith, O'Neill, and Ingram would undoubtedly be a setback for the Vikings. However, the team is focused on finding suitable replacements and adjusting their game plan accordingly. The coaching staff and remaining players will need to step up and deliver strong performances to overcome these challenges and secure another victory.

Despite the potential absences, the Vikings remain confident in their abilities and are determined to maintain their winning momentum. They understand the importance of depth and have faith in the next man up mentality. With their sights set on a 2-0 record, the Vikings will aim to overcome these injury obstacles and come out victorious against a formidable 49ers team on Sunday.