When the San Francisco 49ers take on the Minnesota Vikings for "Monday Night Football" in Week 7, they will be missing two of their top offensive starters. Wide receiver Deebo Samuel and left tackle Trent Williams have been ruled out of the game due to injuries, while running back Christian McCaffrey will be active despite dealing with an oblique injury.

Deebo Samuel, who suffered a shoulder injury during the team's Week 6 loss to the Cleveland Browns, will also miss the Week 8 matchup against the Cincinnati Bengals. Coach Kyle Shanahan informed reporters that Samuel's shoulder injury has been diagnosed as a hairline fracture, and the earliest he can return to the field is in Week 10 when the 49ers face the Jacksonville Jaguars on October 12th.

On the other hand, Trent Williams, a perennial Pro Bowler, will be replaced at left tackle for only one game. Williams has a longstanding history of injuries and has not played a full season in the past decade. However, he is expected to return to the starting lineup soon.

While the 49ers will miss the presence of Samuel and Williams, they can take solace in the fact that Christian McCaffrey will be available to play. McCaffrey, who has been dealing with an oblique injury, participated in a limited practice on Saturday. Since being acquired by San Francisco approximately a year ago, McCaffrey has not missed a game due to injury.

In addition to the absences of Samuel and Williams, linebacker Dre Greenlaw was listed as questionable with a hamstring injury. However, he will be ready to play in Monday's game against the Vikings.

The 49ers, led by coach Kyle Shanahan, will have to rely on their depth and versatility to overcome the absences of their key starters. The matchup against the Vikings will be a test for the team as they aim to maintain their strong performance in the competitive NFC West division.

As the 49ers face the Vikings on Monday, football fans will be watching closely to see how their replacements perform and how McCaffrey's injury affects his performance. The game will undoubtedly showcase the resilience and determination of the 49ers as they strive to secure a victory and continue their quest for a successful season.

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