San Francisco, CA - In a blow to the San Francisco 49ers' offense, wide receiver Deebo Samuel and left tackle Trent Williams have been ruled out for Monday Night Football against the Minnesota Vikings. However, star running back Christian McCaffrey is set to play despite dealing with an oblique injury.

Deebo Samuel, who has been an essential weapon for the 49ers, will not be on the field due to a shoulder injury sustained in the team's Week 6 loss to the Cleveland Browns. The versatile wide receiver is also expected to miss the Week 8 matchup with the Cincinnati Bengals, and his return is not likely until Week 10 against the Jacksonville Jaguars on October 12th. Samuel's absence will be keenly felt by the 49ers' offense.

Meanwhile, left tackle Trent Williams will also be sidelined as he recovers from an ankle injury. This is not the first time Williams has missed games during his tenure with the 49ers, as he has struggled with durability throughout his career. However, the team hopes to have him back in action soon, as his absence will require a temporary replacement at left tackle.

On a positive note, Christian McCaffrey, acquired by the 49ers a year ago, will be active for Monday Night Football. Despite nursing an oblique injury, McCaffrey has managed to avoid missing a game due to injury since joining the team. His presence on the field will be crucial for the 49ers' offensive game plan.

In other injury news, starting linebacker Dre Greenlaw, who was listed as questionable for Monday's game with a hamstring injury, is expected to be ready to play. Greenlaw's availability will provide a boost to the 49ers' defense.

As the 49ers prepare to face the Vikings in Week 7's Monday Night Football matchup, the absence of Deebo Samuel and Trent Williams will pose challenges for the team. However, with the return of Christian McCaffrey and the potential involvement of Dre Greenlaw, the 49ers hope to overcome these setbacks and secure a victory in a crucial game.

The 49ers will need to rely on their depth and execute their game plan effectively as they face a tough opponent without two key starters. The resilience and adaptability of the team will be put to the test on Monday night.