In their final regular-season game, the San Francisco 49ers are set to rest some of their star players and provide valuable playing time to their reserves as they take on the Los Angeles Rams. With the top seed already secured, both teams understand that the upcoming playoff run holds more significance than the outcome of this game.

Head coaches Kyle Shanahan of the 49ers and Sean McVay of the Rams will employ game plans reminiscent of preseason matches, aiming to avoid unnecessary risks. However, with limited active players and several already designated as inactive due to injury or rest, some front-line players will have to assume a potential injury risk by taking the field.

Running backs Elijah Mitchell and Jordan Mason will step in for the rested Christian McCaffrey, while Ty Davis-Price could potentially be activated from the practice squad. Other key players expected to have a reduced workload include left tackle Trent Williams, tight end George Kittle, wide receivers Brandon Aiyuk and Deebo Samuel, edge rusher Nick Bosa, defensive tackle Javon Hargrave, linebackers Fred Warner and Dre Greenlaw, and cornerbacks Charvarius Ward and Deommodore Lenoir.

Both Warner and Bosa emphasized the importance of playing their usual game and not holding back to avoid injury. Shanahan understands the challenge of managing player minutes effectively, ensuring their minds are focused and ready to play.

For the veterans who joined the 49ers mid-season, this game provides an opportunity to further familiarize themselves with the team's system and be better prepared for the upcoming playoff run. Additionally, it allows young veterans and rookies, who have had limited playing time thus far, to showcase their skills in a full-speed environment.

Defensive coordinator Steve Wilks expressed excitement at seeing these players step up and perform, emphasizing the team's unwavering standard regardless of who is on the field.

Among the players to watch in this game are strong safety Logan Ryan, who has impressed with his professionalism and communication, and defensive tackle Sebastian Joseph-Day, who is adjusting to the 49ers' defensive scheme after playing in a different system in the past. Tight end Charlie Woerner, known for his blocking abilities, hopes to make an impact in the passing game as well. Other players like left tackle Jaylon Moore, wide receiver Ronnie Bell, guard/center Ben Bartch, and linebackers Dee Winters and Jalen Graham will also have the opportunity to prove their worth.

As the regular season comes to a close, the 49ers aim to strike a balance between resting their star players and giving their reserves vital playing time. The outcome of this game may hold less significance, but it serves as a valuable stepping stone towards the team's ultimate goal - a successful playoff run.