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The Kansas City Chiefs, the reigning two-time Super Bowl champions, face significant obstacles as they prepare for their Monday Night Football showdown against the New Orleans Saints at 8:15 p.m. ET. Despite starting the season strong with a 4-0 record, key injuries to running back Isiah Pacheco (leg) and wide receiver Rashee Rice (knee) are causing concern. These absences put added pressure on star quarterback Patrick Mahomes, who recently led the team to victory over the Chargers by completing 19 of 29 passes for 245 yards and one touchdown. Tight end Travis Kelce emerged as a key player in that game, securing seven receptions for 89 yards.

Kelce is again expected to be a focal point in the upcoming game, with his receiving yards set at 56.5 in the Week 5 NFL odds. Another player to watch is Xavier Worthy, whose receiving total is pegged at 41.5. It will be a defensive battle, given that the Saints are ranked sixth in the NFL in points allowed per game at 17.5, with the Chiefs close behind in the seventh spot, allowing 18.0 points per game.

Given the strength of both defenses, bettors may lean towards players going under their projected totals. SportsLine's AI PickBot, a prediction tool developed using advanced artificial intelligence and machine learning by SportsLine’s Data Science team, offers valuable insights. By analyzing historic player data and evaluating opponent defenses, the AI assigns a numeric matchup score to formulate predictions. Last season, the AI PickBot achieved an impressive record, hitting 1,674 4.5- and 5-star prop picks. This season, it has already hit 128 picks rated 4 stars or higher.

For the Chiefs vs. Saints matchup, the AI PickBot specifically suggests that Saints quarterback Derek Carr will go under 211.5 passing yards. Carr has shown inconsistency, falling below 200 passing yards on six occasions last season, while also exceeding the 300-yard mark six times. Recently, Carr managed just 142 passing yards in a game against the Eagles. Facing a strong Chiefs defense in a challenging environment, the AI PickBot predicts Carr will struggle to surpass 211.5 passing yards.

Additionally, Carr has thrown an interception in each of his last three games and has been sacked in all games this season. With the Saints boasting a top-10 rushing attack led by Alvin Kamara, the AI PickBot projects Kamara will receive nearly 20 carries, further limiting Carr’s passing opportunities. Based on this comprehensive analysis, the AI PickBot's recommendations can be crucial for bettors looking to make informed prop bets on the Chiefs vs. Saints game.

For in-depth prop picks and to leverage the AI PickBot's expertise, visit SportsLine’s platform where you can access all the detailed predictions and increase your chances of making successful bets.