In Indianapolis, the Chicago Bears faced a tough defeat against the Indianapolis Colts with a score of 21-16 at Lucas Oil Stadium. Despite a strong effort in the fourth quarter where they scored their only two touchdowns of the game, the Bears struggled to bridge the double-digit deficit. Quarterback Caleb Williams showcased an impressive performance, achieving career highs in passing categories with 33 completions, 363 yards, and throwing his first two NFL touchdown passes. However, Williams also accounted for three turnovers, with two interceptions and a lost fumble during the match.

Rookie wide receiver Rome Odunze had a standout game, catching six passes for 112 yards and securing his first NFL career touchdown. DJ Moore contributed with eight receptions for 78 yards, while tight end Cole Kmet added 97 yards on 10 catches. The Bears' rushing game struggled, only managing to gain 63 yards on 28 attempts. Roschon Johnson led the ground game with 30 yards on eight carries, followed by D'Andre Swift with 20 yards on 13 attempts.

The game kicked off with the Bears advancing into Colts territory, but Cairo Santos missed a 56-yard field goal attempt. Despite Williams' solid completions to Kmet and Moore, the Bears were unable to convert. The Bears defense thought they had a key takeaway early in the game, but a ruling on forward progress negated the potential turnover. They later capitalized on a Tremaine Edmunds interception in the end zone, contributing to a hard-fought defensive effort throughout the game.