In NFL Week 15, quarterbacks Matthew Stafford of the Los Angeles Rams and Patrick Mahomes of the Kansas City Chiefs are set to take advantage of their respective matchup angles against opposing defenses. Both signal-callers have the opportunity to shine as they face depleted and blitz-heavy defenses, presenting prime betting opportunities for savvy gamblers.

One of the standout matchups to watch is Matthew Stafford against a struggling Washington Commanders front. As a quarterback who thrives within the structure of his offense, Stafford is expected to excel against a Washington defense that ranks last in pressure rate and second-to-last in quick pressure rate since the team traded Chase Young and Montez Sweat. With a top-five PFF grade and ranking top-10 in expected points added (EPA) per dropback from a clean pocket, Stafford's dominance is likely to continue against a weak pass rush and a Commanders secondary that has been leaking explosive plays. This presents enticing betting options such as the Rams team total, Rams spreads, and parlays involving Stafford and Rams alt spreads.

Meanwhile, Patrick Mahomes, despite experiencing some struggles compared to previous seasons, remains one of the best quarterbacks in the game. His skill set perfectly aligns with the matchup against the New England Patriots' blitz-heavy and man-heavy scheme. The Patriots have blitzed at the fourth-highest rate in the NFL this season, providing Mahomes with an opportunity to showcase his expertise against the blitz. Over his career, he has been the best quarterback in the NFL against the blitz, ranking fifth in EPA per play against this defensive strategy in 2023. Additionally, the Patriots' frequent usage of man coverage plays into Mahomes' strengths, as he has proven to be dominant against man coverage throughout his career. Opportunities for betting on Chiefs spreads, Mahomes passing props, and same-game parlays combining these two bets are worth considering given Mahomes' success against the Patriots' defensive tendencies.

As Week 15 approaches, NFL fans and bettors should keep a close eye on Matthew Stafford and Patrick Mahomes as they exploit advantageous matchups against their respective opponents. With Stafford utilizing the structured offense against a struggling Washington Commanders defense and Mahomes capitalizing on the New England Patriots' blitz and man-heavy scheme, there are plenty of betting options to explore. These matchups have the potential to significantly impact the outcomes of their respective games and provide exciting opportunities for those looking to place wagers on the action.