Los Angeles, CA - Matthew Perry, best known for his role as Chandler Bing in the hit sitcom "Friends," tragically passed away at the age of 53. The Los Angeles County Medical Examiner's Office released a toxicology report confirming the cause of death as "the acute effects of ketamine." The manner of death was ruled an accident.

According to the report, Perry had been undergoing ketamine infusion therapy to treat his depression and anxiety prior to his untimely demise. The toxicology report indicated that the high levels of ketamine found in his postmortem blood specimens could have led to cardiovascular overstimulation and respiratory depression, resulting in a fatal outcome.

On Saturday, October 28, 2023, authorities discovered Perry's lifeless body in a hot tub at his Los Angeles home. There were no signs of foul play or drugs at the scene. TMZ reported that first responders were called for a cardiac arrest.

The news of Perry's passing sent shockwaves through the entertainment industry and his "Friends" co-stars - Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc, and David Schwimmer - released a heartbroken statement expressing their devastation.

"We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family," the statement read. "There is so much to say, but right now we're going to take a moment to grieve and process this unfathomable loss."

Perry's co-stars took to social media to share their personal tributes. Jennifer Aniston revealed that she had been texting with Perry on the day of his death, describing him as happy and healthy. Courteney Cox shared a blooper video from the set of "Friends," expressing her gratitude for every moment spent with Perry.

The late actor had been open about his struggles with addiction throughout his career and published a memoir titled "Friends, Lovers and the big Terrible Thing" in 2022. In light of his passing, the Matthew Perry Foundation was established to support individuals dealing with addiction.

The legacy of Matthew Perry, who brought laughter and depth to his iconic role as Chandler Bing, will be remembered by his fans and the entertainment industry. As Variety's chief correspondent Daniel D'Addario noted, Perry's struggles and his ability to channel both wit and underlying sadness in his performances will continue to resonate with audiences.