The highly anticipated UFC event, UFC on ESPN 59, is set to take place at Ball Arena in Denver, the birthplace of UFC 1. With a former champion and local fan favorite leading the card, the excitement is palpable among MMA enthusiasts.

The main card features thrilling matchups between some of the most skilled fighters in the Middleweight, Featherweight, Welterweight, Lightweight, and Women's Flyweight divisions. For this event, 11 editors, writers, radio hosts, and videographers have shared their pick results, providing additional analysis for fans.

In the Middleweight division, Abdul Razak Alhassan (12-6 MMA, 6-6 UFC) is set to face off against Cody Brundage (10-6 MMA, 4-5 UFC). Alhassan holds a slight advantage, with the odds favoring him at -170, compared to Brundage's +140. The majority of the Junkie panel picks Alhassan as the victor, with a 7 to 4 score.

In a Featherweight clash, Julian Erosa (29-12 MMA, 7-7 UFC) will go up against Christian Rodriguez (11-1 MMA, 4-1 UFC). Despite being the underdog, with odds of +195, Erosa's experience in the octagon cannot be overlooked. However, Rodriguez is favored in this bout, with a -230 odds. The Junkie panel leans heavily towards Rodriguez, 9 picks to 2.

The Welterweight division brings Gabriel Bonfim (15-1 MMA, 2-1 UFC) against Ange Loosa (10-3 MMA, 2-1 UFC). Bonfim stands as the favorite with -340 odds, whereas Loosa's odds stand at +270. The experts are overwhelmingly in favor of Bonfim, with a staggering 10 to 1 pick in his favor.

Drew Dober (27-13 MMA, 13-9 UFC) and Jean Silva (13-2 MMA, 2-0 UFC) will face off in a Lightweight showdown. The odds for this bout are virtually even, with Dober at -105 and Silva at -115. The panel presents a slightly closer score, with 7 picks for Dober and 4 for Silva.

In a compelling clash in the Welterweight division, Santiago Ponzinibbio (29-7 MMA, 11-6 UFC) takes on Muslim Salikhov (19-5 MMA, 6-4 UFC). Ponzinibbio holds the advantage with -185 odds, while Salikhov's odds sit at +155. The Junkie panel predicts a highly contested match, with Salikhov edging slightly ahead with 6 picks to Ponzinibbio's 5.

Lastly, in a Women's Flyweight bout, Rose Namajunas (13-6 MMA, 10-5 UFC) squares off against Tracy Cortez (11-1 MMA, 5-0 UFC). Namajunas holds the favored position with -225 odds, while Cortez stands as the underdog at +185. The panel overwhelmingly picks Namajunas to secure the victory, with 9 picks in her favor compared to Cortez's 2.

For UFC fans eagerly awaiting these matchups, the main card picks provide valuable insight into the potential outcomes. With a mix of favorites and underdogs, the stage is set for an exhilarating night of world-class mixed martial arts action in Denver on Saturday.

(Note: This article is based solely on the information provided in the context and does not include any additional information beyond what was given.