Top Doctors Urge Caution as Multi-Cancer Detection Tests Raise Concerns

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01/06/2024 16h27

These tests claim to detect numerous types of cancer and are seen as potential alternatives to invasive screenings like colonoscopies and mammograms. However, experts at the American Society of Clinical Oncology meeting in Chicago expressed reservations and advised sticking to regular screenings.

MCDs primarily rely on blood draws to identify abnormal proteins and cells associated with cancer. Similar to full-body MRI scans endorsed by celebrities like Kim Kardashian and Gwyneth Paltrow, many MCDs claim to detect cancer in its early stages, even before symptoms manifest. Despite initial encouraging studies, doctors emphasized that MCDs are not yet recommended for patients and are not ready for widespread use.

One of the concerns raised by experts is the risk of false positives, which could result in unnecessary and costly follow-up tests for patients. Additionally, MCDs are not covered by insurance, with each test costing over $1,000. The Food and Drug Administration (FDA) has deemed the Shield blood test from Guardant as safe but acknowledges the need for further research on MCDs.

The warnings come at a time when health officials are lowering the age guidelines for colorectal and breast cancer screenings due to an increase in young people being diagnosed with these diseases. Dr. Chyke Doubeni, a family medicine physician at Ohio State University, stated that the evidence for MCDs is currently lacking and that the potential harm associated with these tests must be taken into consideration.

Recent reports have shown promise for MCDs, including studies from the University of Oxford. One study found that proteins in blood samples differed in individuals diagnosed with cancer compared to those without the disease. Another study identified 40 proteins in the blood that influenced the risk of nine different types of cancer. The Galleri test, which claims to detect 50 types of cancer, was found to be 93% accurate in detecting 18 types of early-stage cancers.

Despite these positive findings, experts suggest that more in-depth research is necessary before relying heavily on MCDs for early detection. Dr. Robert A Smith, an oncology researcher at the American Cancer Society, noted that while MCDs could potentially detect cancer at earlier stages, they should not replace regular screenings.

False positives remain a significant concern. The intended audience for these tests is vast, leading to the possibility of unnecessary invasive procedures and increased costs for patients. Strict monitoring and potential limitations by regulatory agencies like the FDA have been suggested to ensure the safe and effective use of MCDs.

In conclusion, top doctors are urging caution regarding multi-cancer detection tests, emphasizing that more evidence is needed before widespread adoption. While there are promising results from initial studies, concerns about false positives, costs, and the need for further research prevail. Regular screenings are still recommended as the primary method for early detection.

The views expressed in this article do not reflect the opinion of ICARO, or any of its affiliates.

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