### Fantasy Football Week 10: Critical Start-Sit Advice for 49ers' Key Players

As the San Francisco 49ers prepare to clash with the Tampa Bay Buccaneers in Week 10, fantasy football enthusiasts are carefully assessing their lineups with crucial start and sit decisions. This guide offers pivotal advice on the 49ers' key players, helping you maximize your points potential.

**Christian McCaffrey's Return**

After being activated from IR, Christian McCaffrey is set for his season debut. Despite the impressive performance of Jordan Mason, who has racked up a 17-game pace of 1,639 yards from scrimmage, McCaffrey's unique talent and versatility make him a must-start. Mason might retain some flex value, but McCaffrey's presence considerably shifts the backfield dynamic.

**Deebo Samuel's Involvement**

Deebo Samuel Sr. is also active for today's game. While McCaffrey's return may slightly impact his touches, Samuel remains integral to the 49ers' offense. Averaging 7.8 touches per game when healthy, Samuel's role appears secure, making him a strong WR2 candidate in all formats.

**Jauan Jennings' Opportunity**

Jauan Jennings, back from a hip injury, will fill in as the 49ers' WR2. Though likely the fourth option in their passing attack, his earlier season performance demonstrated his capability of earning valuable targets. Given that the Buccaneers' perimeter defense is ranked 20th in completion percentage and 25th in touchdown rate, Jennings could emerge as a significant fantasy asset this week.

**Brock Purdy's Rising Fantasy Value**

Quarterback Brock Purdy has been a top-10 fantasy performer in recent weeks. His quick-pass rate has decreased from 74.1% to 55.4%, suggesting more creative play-calling. With the Buccaneers allowing QBs to score over 24.5 fantasy points in their past three games, Purdy is positioned above the streaming tier moving forward.

**George Kittle's Consistency**

For the first time since last October, George Kittle has surpassed 80 air yards in consecutive games. With Brandon Aiyuk sidelined, Kittle's role is cemented, making him a top fantasy TE for the remainder of the season. His stable production provides a significant edge in a position often marred by inconsistency.

**Game Insights**

Historically, the 49ers have excelled post-bye week, evidenced by their six-game winning streak last season, outscoring opponents 207-94. In contrast, the Tampa Bay Buccaneers have struggled, allowing opponents to convert 60% of third downs in the past two weeks compared to 37.2% in the first seven weeks. This disparity could play into the 49ers' favor, enhancing the fantasy value of their key players.

As fantasy football managers navigate Week 10, these insights on the 49ers' roster could be pivotal in optimizing lineups and securing a crucial win.