The Buffalo Bills are set to kick off their 2024 preseason schedule against the Chicago Bears at Highmark Stadium in Orchard Park on Saturday. As fans eagerly await the start of the game, here are five things to keep an eye on during the matchup.

First and foremost, all eyes will be on Bills quarterback Josh Allen as he takes the field with the starting offense. Head coach Sean McDermott has confirmed that Allen and the rest of the starters will see some playing time, but the focus will be on building chemistry with new teammates and getting into a rhythm. With a largely revamped group, efficiency and health will be key for the Bills' offensive unit as they prepare for the regular season.

On the other side of the field, Bears' rookie quarterback Caleb Williams will make his highly-anticipated professional debut. As the No. 1 overall draft pick, his performance will undoubtedly be of great interest to both Bears and Bills fans alike. Williams' playing style and ability to adapt to the professional level will be under scrutiny as he leads the Bears' offense.

Another aspect to watch out for is the wide receiver battle on the Bills' roster. While the top four receiver slots appear to be relatively set with Curtis Samuel, Khalil Shakir, Keon Coleman, and Mack Hollins, there are several other contenders vying for a place on the team. Tyrell Shavers has impressed with his strong case to secure a spot, while Marquez Valdes-Scantling, KJ Hamler, and Andy Isabella will aim to make a lasting impression during the preseason.

Defensively, the Bills' backup cornerback, Elam, has shown promise in training camp and will be looking to solidify his role as a reliable backup to Christian Benford. With injuries to Mike Edwards and Cole Bishop, Damar Hamlin has the opportunity to step up as a starter opposite Taylor Rapp. Hamlin has showcased steady and solid play throughout the offseason, but the preseason will test his ability to perform consistently in a full-time starting role. Behind these starters, the Bills' defensive depth will be put to the test, potentially calling upon various players to step in if needed.

Lastly, the preseason opener will provide insight into how the Bills adapt to the new kickoff and kick return rules. The team's approach to these rule changes will be intriguing to witness, as they aim to maximize their effectiveness in special teams.

As the Bills and Bears clash in their preseason opener, fans will be keen on witnessing the chemistry of the Bills' revamped offense, the debut of Caleb Williams, the wide receiver battles, the depth of the Bills' defense, and the team's strategic approach to the new NFL rules. It will undoubtedly be an exciting and thought-provoking game, setting the stage for an action-packed preseason.